- Title
- Dynamic multistimuli-responsive reversible chiral transformation in supramolecular helices
- Creator
- Goskulwad, Santosh; La, Duong Duc; Al Kobaisi, Mohammad; Bhosale, Sidhanath V.; Bansal, Vipul; Vinu, Ajayan; Ariga, Katsuhiko; Bhosale, Sheshanath V.
- Relation
- Scientific Reports Vol. 8, no. 11220
- Publisher Link
- http://dx.doi.org/10.1038/s41598-018-29152-9
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2018
- Description
- The design of new chiral chromophores that allow tunable assembly of higher order helical structures by using natural stimuli offers promising avenue in understanding various biological processes. In particular, access to dynamic multistimuli-responsive systems can provide real-time monitoring of chiral transformation in chemical and biological systems. We report on the synthesis of naphthalenediimide appended L-glutamate (NDI-L-Glu) that self-assembles into chiral supramolecular structures under physiological conditions. Specifically, NDI-L-Glu shows a mixture of left- and right-handed helices under physiological conditions, and any deviation from the ambient biochemical environment has a remarkable influence on the chirality of these structures. For instance, acidic environments shift the helicity to left-handedness while the alkaline conditions reversed the helical structures to right-handedness, thereby mimicking the molecular virulence mechanism of tobacco mosaic virus (TMV). The chirality of these supramolecular assemblies can also be controllably tuned by using temperature as an external stimulus, allowing reversible flip of helicity.
- Subject
- chiral chromophores; helical structures; supramolecular helices
- Identifier
- http://hdl.handle.net/1959.13/1404375
- Identifier
- uon:35327
- Identifier
- ISSN:2045-2322
- Rights
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
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